What is Royal jelly?
Royal jelly (RJ) is a yellowish white, creamy liquid secreted by the mandibular and hypopharyngeal glands of the nurse bees
It’s composed mainly of important compounds with biological and health-promoting activities such as proteins, lipids, sugars, vitamins, minerals, and free amino acids.
Royal jelly composition
- large number of bioactive substances are present in RJ such as antimicrobial peptides (royalisin and jelleins) , peptides with antihypertensive activity,
and sterols and fatty acids with estrogenic effects, like the 10-hydroxy-2- decanoic acid (10H2DA).
- RJ contains vitamins such as riboflavin, thiamine, niacin, folic acid, biotin, and pyridoxine and smaller amounts of vitamins C, D, A, and E .
- The main minerals in RJ are calcium, sodium, potassium, copper, iron, zinc, and manganese.
Source of Royal jelly
- Royal Jelly is a cream product created by young nurse worker bees for feeding to the queen, queen larvae and other young larvae.
- Royal jelly is ‘Food source of Queen Bees’ as Queen Bees ingest royal honey for their entire life, That’s whys it’s called Royal jelly
- RJ also presents several pharmacological properties, such as antibacterial, antifungal, antihypertensive, and estrogenic activities.
- Due to its pharmacological properties, RJ is used to supplement the treatment of several diseases, in many countries.
Benefits of Royal jelly
- Six-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health.
- Royal jelly enhances fatigue, furthermore it’s used to ameliorate cancer related fatigue (CRF)
Lyophilization of Royal jelly
- Fresh and lyophilized RJ maintained their 10H2DA contents and were effective against the bacteria
- The lyophilization process maintains the chemical and antibacterial properties of RJ.
Royal jelly Role in antibiotic resistance
- The fatty acid 10H2DA exhibited a good antibacterial activity against S.pneumoniae.
- It may be used as an alternative and complementary treatment for infections caused by antibiotic resistant S.pneumoniae.
- The major antibacterial property of RJ is attributed to the fatty acid of 10HDA, several antimicrobial peptides have been found in RJ containing apisimin, apalbumin α, jeleines I, II, III, and IV, and royalactin
- The ether-soluble fraction of RJ is also effective against bacteria such as Staphylococcus aureus, Escherichia coli, Streptomyces griseus, and three unclassified strains of Streptomyces
RJ exhibited a wide spectrum of antifungal activities against Aspergillus fumigants, Aspergillus niger, Candida albicans, and Syncephalastrum racemosum.
Antiviral effect of Royal Jelly
- Royal jelly has the highest inhibitory effects on HSV-1 at concentrations of 250 μg/mL
- In addition,royal jelly decreased the viral load from 70 795 to 30 PFU/mL at a concentration of 100 μg/mL.
- Early research shows that taking royal jelly by mouth for 3 months can increase LDL cholesterol and decrease HDL cholesterol in postmenopausal women.
- Other research shows that taking a product containing royal jelly and flower pollen by mouth for 12 weeks can reduce menopausal symptoms and improve feelings of well-being in menopausal women.
- RJ has a protective role against oxidative stress in liver and renal tissues exposed to carbon tetrachloride and cisplatin.
- Royal jelly helps in increasing activities of the main cellular antioxidant enzymes such as glutathione reductase (GR), glutathione peroxidase (GPX), superoxide dismutase(SOD), and CAT
Effects on fertility
- For human studies, one conducted in infertile men using Royal Jelly at 25, 50, and 100mg daily for 3 months was able to increase testosterone by 22.01%, 19.8%, and 20.4%
- In infertile men, all tested doses of Royal Jelly (25, 50, and 100mg) daily were able to increase libido.
New findings of royal jelly
Administration of RJ (150 mg) for three months has been shown to lead to dramatic improvement of serum lipid factors (reduction of total cholesterol and LDL and increase of HDL) of postmenopausal women.
Drinkable Royal jelly with artificial sweetener sorbitol and natural orange flavor.
Lyophilized royal jelly 333 mg (corresponding
to 1000 mg fresh)
Royal jelly is POSSIBLY SAFE for most people when taken orally.
Pregnancy and lactation
- There is not enough reliable information about the safety of using royal jelly if you are pregnant or breast-feeding.
- Stay on the safe side and avoid use.
Precautions and Contraindications
- Don’t use royal jelly if you have asthma or allergies to bee products.
- Warfarin (Coumadin) interacts with ROYAL JELLY (Moderate interaction)
- Royal jelly might increase the effects of warfarin (Coumadin). Taking royal jelly with warfarin (Coumadin) might result in an increased chance of bruising or bleeding.
- The pack contains 10 bottles.
- Each bottle contains 9ml
Recommended dose is 1 full bottle per day.
- Directions of use: Shake well before opening
KSA market mainly contains Royal jelly as capsules dosage form while Vitcho is Drinkable royal Jelly:
- Easy swallowing especially for elderly patients
- Better absorption
- 1 Vitcho bottle daily versus 2 capsules so Vitcho increase the patient compliance.